Calcitonin-Gene Related Peptide (CGRP) Antagonists /Monoclonal Antibodies
New Targeted Therapies for Migraine

Migraine has been recognized as a highly disabling neurological pain disorder and its management is often challenging! Despite it being more prevalent than diabetes, epilepsy and asthma combined, efficacious drugs for treating migraine are still wanting. Better drugs for diabetes and asthma have been launched in the last decade but migraine is still being served mostly by the triptan class of drugs launched in the 90’s!

Current treatments, preventive and therapeutic, are not specific and hence efficacy, safety, and tolerability are unsatisfactory. Nearly half of individuals with episodic or chronic migraine who are in need of preventive therapies do not receive them. Migraine remains undiagnosed and undertreated in at least 50% of patients, and less than 50% of migraine patients consult a physician.Growing awareness of the unmet need in migraine has given momentum to the research and understanding of the molecular pathway and physiology of the disease. Novel mechanisms, such as, 5-hydroxytriptamine (5-HT) receptors, Calcitonin-Gene Related Peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), Glutamate etc, show promise for relieving symptoms and may provide more effective treatment option in the near term.CGRP is an extensively studied neuropeptide that has been implicated in the pathophysiology of migraine. Over 20 years of intense research on the target (CGRP) translated into what may be the first class of medications being developed specifically for the prevention of migraine in over 50 years! Several small molecule antagonists against the CGRP receptor demonstrated that targeting this pathway is a valid and effective way of treating migraine.In this report, we highlight the advances made in the understanding of the biology of migraine and development of new drugs for Migraine. Besides new targets, novel drug delivery systems for off patent drugs, devices also are available for the patients.

We discuss why CGRP is a promising target for the prevention of migraine and describe four monoclonal antibodies against either CGRP or its receptor that are in clinical development for the treatment of both episodic and chronic migraine. A comprehensive comparison of clinical data and properties of some of the potential drugs in the pipeline is included in the report.Most of the major CNS players have a drug targeting CGRP in their pipeline. The launch of anti CGRP could probably represent a turning point for prevention similar to that represented by triptans for abortive treatment in migraine. Considering the WW high prevalence of migraine, the market opportunity is immense. The commercial opportunity is discussed in the report.

Research Methodology

Research methodology is based on in-depth research and market study, scientific journals or technical literature, industry publications, company reports and published information, and statistical data from government agencies and other therapy foundation or associations.  Forecasts and projections of market size and future market activity are derived using standard modelling and statistical techniques.

Author Bio

Subita Srimal

ProGrow Pharma (PGP) Partners caters the full spectrum of services to Pharma companies (Pharma/ Biotech, Generic, CRAMS, CROs, Start-ups) and its Investors (Private Equity, Fund Managers, HNI).  With decades of experience in strategic advisory, regulatory aspects, technical publications, understanding complex drugs, identifying market potential and all related services, the team is widely approached by pharmaceutical companies and experts.  Our team can support you from defining strategic programmes to providing expert guidance for tactical operations to transform your operational or market based challenges into growth aligned opportunities.

  1. Executive Summary
  2. Targeting Calcitonin Gene-Related Peptide (CGRP) in Migraine
    • Rationale for Targeting CGRP
    • Biology: Structure and Molecular Genetics of CGRP
    • Development of CGRP Antagonists for the Treatment of Migraine
    • Non-Tritpan Drugs and Other “Me-too’s” in the Pipeline
    • Commercial Opportunity
    • Merger and Acquisitions / Licensing Opportunity
  3. Migraine
    • Overview of the Disease
    • Pathophysiology of the Disease
    • Epidemiology
    • Subtypes of Migraine
    • Signs and symptoms of Migraine
    • Causes of Migraine
    • Risk factors
    • Diagnosis and Current Treatment Paradigm
    • Unmet need
  • Novartis
  • Eli Lilly
  • Teva
  • Alder Biopharma
  • Allergan
  • Otsuka
  • Biohaven
  • Avanir Pharma
  • IntelGenx
  • RedHill Biopharma
  • CoLucid Pharma
  • Zosano Pharma
  • Merck
  • Dr Reddy's Lab
  • NeurAxon
  • Acorda Therapeutics
  • Pfizer
  • Amgen
  • Trigemina
  • Suda
  • Achelios Therapeutics
  • Impax Laboratories
  • AstraZeneca
  • BMS
  • Heptares Therapeutics
  • Labrys Biologics
  • GSK
  • NuPathe
  • Arteaus Therapeutics
  • MAP Pharma
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